Study of Transfusion transmittable Infections Seroprevalence among blood donors in a tertiary care Hospital of central India; Research Article - Biomedical Review: Journal of Basic and Applied Medical Sciences (JBAMS) by Siddharth Health Research and Social Welfare Society

Study of Transfusion transmittable Infections: Seroprevalence among blood donors in a tertiary care Hospital of central India; Research Article

Vivek Khare
India

30-Jun-2014 12:00 AM 94449

Introduction: Transfusion-transmissible infectious agents such as hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem. This cross-sectional study was undertaken with the aim of determining the seroprevalence of HIV, HCV, hepatitis B surface antigen (HBsAg) and syphilis and correlates the findings with sex and age to ascertain the associations if any in the occurrence of the pathogens. Material and Methods: Microwell ELISA (Enzyme Linked Immunosorbent Assay) test for the detection of Hepatitis B surface Antigen (HBsAg), antibodies to HIV types 1 and 2 & antibodies to HCV were determined using kits manufactured by J. Mitra & Co. Pvt. Ltd. For syphilis and Malaria detection test strip manufactured by Aspen & Co. were used. Result: A total of 1510 apparently healthy prospective blood donors aged between 18 and 60 years who presented for blood donation at L N Medical College & J.K. Hospital Blood Bank were studied. The male:female ratio was 6:1. Of the prospective blood donors, 21 (28.8%) had serological evidence of infection with at least one infectious marker. The overall seroprevalence of HBsAg, HIV, HCV and syphilis was found to be 18.6%, 3.1%, 6.0% and 1.1%, respectively. Discussion: The high seroprevalence of blood-borne pathogens among prospective blood donors in Bhopal (Central India) calls for mandatory routine screening of blood donors for HBV, HIV, HCV, Syphilis and Malaria.

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