31-Dec-2021 12:00 AM
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Combined Oral Contraceptions (COCs) is widely used as an effective and reliable method for pregnancy prevention, as well as for other important noncontraceptive reasons, including reducing menstrual pain and cramping,reducing heavy bleeding or menorrhagia, normalizing irregular periods and treating pelvic pain associated with endometriosis, among others. As the evidence of COCs impacts on some biochemical biomarkers related to diseases such as cardiovascular disease, diabetes, systemic high blood pressure, inflammatory disease, stroke, cancer etc. is inconclusive, contradictory and limited by methodological inconsistencies, we did a systematic review, searching on PubMed and Embase, aiming to investigate the possibility of an association between consumption of the various forms of hormonal contraception and biomarkers levels alteration and also to identify, collate and critically appraise studies assessing the influence of hormonal contraceptives on these diseases spectrum and expose available scientific evidence to create individualized plans to prescribe oral contraceptives for patients based on their needs, lifestyles, co morbidities, and reproductive plans.
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