A prospective blinded randomized controlled trial of use of preoperative antibiotics in routine abdominal surgery A comparison between single dose versus three doses between Ofloxacin + Metronidazole - Biomedical Review: Journal of Basic and Applied Medical Sciences (JBAMS) by Siddharth Health Research and Social Welfare Society

A prospective blinded randomized controlled trial of use of preoperative antibiotics in routine abdominal surgery: A comparison between single dose versus three doses between Ofloxacin + Metronidazole and Cefotaxime + Sulbactum; Research Article

Narendra N Ganguly
India

31-Dec-2015 12:00 AM 13414

Introduction: Anti microbial prophylaxis before any elective surgery is preferred deterrent post operative surgical site infection now. Many regimes with different antimicrobial agents are tried and most institutions have developed their own regime or philosophy to address postoperative surgical site infection. We have also our own antibiotic prophylaxis and protocol. Method: A total of 138 patients (above 16 years) were taken for study. It was randomized and blind study. Patients were prospectively analysed. First, patients were divided into two groups. Those who have received single dose antibiotic at incision and those who received two more doses after first dose. Open elective as well as laparoscopic elective procedures have included study. Routine practice of preoperative bath, preoperative preparations of the area with iodophores and spirit, operating under normothermia and hydration were as per institutional philosophy and common to all the patients. Two combinations compared: Cefotaxime+ Sulbactum & Ofloxacin + Metronidazole. Keeping outcome of study in mind all materials were analysed and statistical analysis done and confidence intervals were noted. Results: Study revealed interesting observations. Single dose pre operative prophylaxis scored over three doses regime in all cases for lap surgery. Conclusion: Multiday and antibiotics use for prolonged period is not advisable these days after a routine elective abdominal surgery.

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