Chronic nonspecific musculoskeletal pain in adults with special reference to serum uric acid levels; Research Article

30-Jun-2015 12:00 AM 7665

Introduction: Increased serum uric acid levels have been found to be variably associated with chronic nonspecific musculoskeletal pain in different subgroups of population. Tresent study is aimed knowing association increased serum uric acid levels in adult population with chronic nonspecific musculoskeletal pain. Primary outcome measure was to know levels of serum uric acid levels in patients with chronic nonspecific musculoskeletal pain and, secondary outcome measure was to know effect of Hypouricemic agents Febuoxastat in patients with hyperuricemia. Methods: One hundred and twenty five (n=125) adult patients (M: F-63:62) having chronic nonspecific musculoskeletal pain of ≥ 6 weeks duration were included in study and, their serum uric acid levels were estimated. An eleven points (0-10) Numerical Rating Scale (NRS) was used to assess level of chronic musculoskeletal pain in study participants. Patients with hyperuricemia were given oral Hypouricemic drug febuoxastat. Study was conducted for period one year. Results: Serum uric acid levels were raised in a significant proportion (p value ˂0.0001) of patients (70.4%) with chronic nonspecific musculoskeletal pain. Mean serum uric acid level was 8.3mg/dl in 70.4% (n=88) patients and 5.6 mg/dl in 20 %( n=25) patients. Mean serum uric acid level was below 2.0mg/dl (1.85±0.10mg/dl) in the remaining 9.6% (n=12) patients. Among the 88 patients having higher mean serum uric acid levels 39.2% (n=49) were female and 31.2 %( n=39) were male patients. Conclusion: Increased serum uric acid levels have an important role in development and pathogenesis chronic non specific musculoskeletal pain in adults. Both increased and decreased serum uric acid levels can cause symptomatic chronic nonspecific musculoskeletal pain.

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Determining the role of intra-uterine contraceptive device, oral contraceptive pills and multiple sexual partners in altered vaginal flora leading to bacterial vaginosis, in patients attending a tertiary care hospital in central Maharashtra, India; Research Article

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