Antimicrobial activity of Maha Megarajanga thailam (MMRT) against Staphylococcus aureus and Methicillin Resistant Staphyloccus aureus (MRSA)

31-Dec-2024 12:00 AM 3327

Subramanian S1, Gnanamani A2, Pushkala VP3, H Subhashree4*, K Yazhini5

Staphylococcus aureus is primarily responsible for the persistent infections in chronic wounds. From 2015 to 2019 the generic prevalence of MRSA was found to be 37%. There has been a gradual increase in the prevalence rate of MRSA over a period of time. There is uniform reporting of prevalence rate in all zones of India. One of the most serious global public health concern of this century is Antimicrobial resistance (AMR). World Health Organization (WHO) has emphasized that MRSA is one of the high priority pathogen among multidrug-resistant organisms. Maha Megarajanga Thailam mentioned in the text Theraiyar Taila Varga Surukkam is an unique preparation used externally as well as internally. It has castor oil as base with more than 180 plant parts and minerals as ingredients. It has got unique therapeutic values against skin lacerations, burns, contusions, and diabetic wounds. Vaidyar Sachidananda Swamy has prepared this unique preparation for the past 40 years and has implemented it clinically. The agar well diffusion assay and broth dilution assays were used to determine the antibacterial activity of MMRT. The former is considered to be the gold standard of susceptibility testing which permits detection of contamination and microbial heterogeneity readily whereas broth dilution enables the reproducibility and economy of reagents. The results prove that MMRT is potent against Staphylococcus aureus and MRSA. It inhibits bacterial growth and has been proven to be effective in management of diabetic wounds and skin infections.

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