Adverse Drug Reactions Monitoring in Inpatients department of tertiary care Teaching Hospital; Research Article

30-Jun-2014 12:00 AM 86424

Introduction and Objectives: The aim of study was to detect, document and to do causality analysis of ADRs in In-patients of tertiary care teaching hospital. Method: It is a prospective observational study being conducted in a tertiary care hospital of central India. In addition to spontaneous voluntary reporting system, an active search was also used to collect ADRs. The data collected was recorded on standard ADR reporting forms. Each reported form was then assessed for its causality and severity as per the standard criteria. Results: A total of 171 ADRs in 126 patients were detected. Out of which 66.1% ADRs occurred in males and 33.9% ADRs in females. Majority of the ADRs were related to the gastro-intestinal system (50.29%), with vomiting and nausea being the most common. Maximum number of ADRs were due to Antitubercular drugs (58.48%). The causality assessment as per Naranjo’s scale showed that out of 171 ADRs, 98.83% were probable and 1.16% were possibly due to drug use. According to the WHO probability assessment scale, 66.66% were in possible and 33.33% ADRs were in probable categories respectively. Severity assessment by modified Hartwig and Siegel scale showed that 74.27% ADRs were mild and 25.73% were moderate. Conclusion: Considering the magnitude of ADRs related problems, there is a need for greater awareness among health care professionals to detect and report them. These ADRs if recognised in time and managed properly can prevent treatment interruption

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